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ORIGINAL ARTICLE
Year : 2022  |  Volume : 19  |  Issue : 1  |  Page : 24-28

Cholinergic stimulation of fracture healing: An animal study


1 Department of Orthopaedics, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India
2 Pushpagiri Research Centre, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala, India
3 Pushpagiri Research Centre, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala; Department of Chemistry, School of Sciences, Jain Deemed to be University, Bengaluru, Karnataka, India

Correspondence Address:
P S John
Department of Orthopaedics, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla - 689 101, Kerala
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/joasis.joasis_21_21

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Background: There have been countless attempts not only to address the problems of a failed union but also to accelerate fracture healing. A review of the literature over the last several decades shows that the various strategies for accelerating fracture healing have not been highly successful. Aims and objectives: Recent discoveries on the positive role of cholinergic activity on bone have been successfully used to investigate new promising therapies for various bone diseases and acceleration of fracture healing based on cholinergic stimulation. Citicoline is a precursor of acetylcholine biosynthesis and can increase the level of acetylcholine and thereby increase cholinergic activity. Hence we have done a study to find out the role of citicoline in accelerating fracture healing. Materials and methods: In this animal experiment model, we have studied the healing of leg fracture in a group of ten rats treated with citicoline injection intraperitoneally and in another group without citicoline supplementation. Results: The citicoline group showed early fracture healing with exuberant callus and the tissues studied from the fracture site showed more thymidine incorporation. Conclusions: This animal study has shown that Citicoline can accelerate fracture healing by cholinergic stimulation.


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